Telomere on DNA strandI want to believe; I really do!  I want to believe that fish oil, specifically MY fish oil, is a telomerase activator!  But there is this little thing called lying that I am not willing to do.

So here is the truth:

I sent my fish oil to Sierra Sciences for telomerase evaluation and it did not turn on telomerase at the typical doses I recommend – 3 to 6 grams a day.

But all was not lost, because of all the supplements I tested (mostly BS stuff claiming to be telomerase activators and of course resveratrol) my fish oil was the only one that came back as “increasing cellular viability”.

What does that mean?  It means that more cells were alive and healthier at the end of the day – sort of a cellular definition of “Healthspan”.

So this reminds me: if people are going to make claims, I really think they should be responsible for testing the statements for truth.  I do it and, in my opinion, it should be the individual responsibility of whoever is selling, to do the same.

But wait, there is more!  There ARE studies that suggest fish oil is indeed a telomerase activator, as well as an inhibitor.

Now if this confuses you, hang in there for just a moment.

There are two important studies that point to fish oil’s actions on the telomere. One involved people with heart disease; the other simply involved sedentary middle-aged people.

Something happened that is far more important than turning on telomerase and maybe even more important than lengthening telomeres.

People in the heart disease group just plain old did better with more fish oil on board – and yes, fish oil was a big part of how they got their levels up, in spite of the ridiculous and unending suggestions that fish somehow contains a magical element. It does, but it is called Omega 3 and it is cleaner and more concentrated in pills.

Also, understand that while avoiding omega 6 fatty acids is really a very good strategy, most people do not do it and wind up relying on supplements. Sorry, gang, it’s just easier and trust me, the gurus in the field are taking supplements, not ingesting mercury from fish!

In the other study, the effects of fish oil on the telomere were directly related to the reduction in inflammatory markers.

I have written a lot about how vulnerable telomeric DNA is to oxidation in a bunch of my recent blogs, so this is not really a surprise.

Now here is the thing: Fish oil may indeed be an indirect telomerase activator by “downstream” signaling molecules, especially if it is used at high enough doses.  No one has really done that study yet, because most people are not taking as much fish oil as I do.

And while the jury is still out on this, there are so many other reasons to take fish oil that it almost doesn’t matter.

Besides, there are two other great things you can take specifically for your telomere supplements: The Telomere Edge Pack telomere support and the world’s only “proven in humans” telomerase activator, TA-65.

In the long run, it is all about length!

 

Doc

 

 

 

Recommended reading:

Brain Behav Immun. 2013 Feb;28:16-24. doi: 10.1016/j.bbi.2012.09.004. Epub 2012 Sep 23.

Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial.

Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E.

Source

JAMA. Author manuscript; available in PMC 2010 February 10.

Published in final edited form as:

JAMA. 2010 January 20; 303(3): 250.

doi:  10.1001/jama.2009.2008

PMCID: PMC2819264

NIHMSID: NIHMS172565

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

Ramin Farzaneh-Far, MD, Jue Lin, PhD, Elissa S. Epel, PhD, William S. Harris, PhD, Elizabeth H. Blackburn, PhD, and Mary A. Whooley, MD

Lipids Health Dis. 2008; 7: 37.

Published online 2008 October 15. doi:  10.1186/1476-511X-7-37

PMCID: PMC2576273

Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules

Undurti N Das 1,2

4 COMMENTS

  1. Fascinating article, great stuff!

    Especially true about unwittingly ingesting toxins like mercury from fresh fish nowadays and also most farmed fish contain very little omega 3 due to their poor diet of pellets.

    I would be interested to know if the DHA omega 3 fatty acids played a larger role in these results, as they are far better for your brain and mental health as opposed to EPA, but I’m sure more studies are on the way!

    • I would be careful about labeling DHA as “better for your brain”. Some 30% of the DHA in the brain is created by Beta Oxidation of DHA and in “brain” studies where DHA alone was used, there have often been no benefits reported. YOU need them both. This is why algae-derived products fall short. And telomeres are everywhere!

      Best,
      Dr Dave

  2. Dr Dave

    Hi
    Would you know by any chance know If Stem cells with no telomerase and the use of fish oil and Ta-65 would increase the length of telomerase on that stem cell (human) and not be damaged?

    Regards
    Steve

    • I am not really sure what this question is but I will say I have never heard of “stem cells with no telomerase”. I can only guess this means sensescent stem cells that have aged to the point where they are no longer of much use. I think TA-65 is very useful for increasing telomerase expression in rapidly dividing cells such as those we harvest and see in bone marrow which includes numerous types of stem cells. In addition TA-65 seems to have the most obvious benefits in aged people like my 88 year old mom who is now in her 5th year of high dose use and will not do with out it!

Leave a Reply